The Glasgow band will take top billing as the event returns after 2020’s postponement, and runs over two days on Friday, September 3, and Saturday 4th.
Organised by Polmont brothers, David and Andy Ure, Vibration will feature several stages, a DJ area and attractions for youngsters.
The festival - which won two industry awards in its inaugural year - says it has a full line-up ready to unveil.
Indie rockers, The Fratellis made their mark with a number of hits including s ‘Chelsea Dagger’, ‘Henrietta’ and ‘Whistle for the Choir.’
Last week the band revealed plans to cover the 1970s Bacarra hit Yes Sir I Can Boogie after it became the anthem of the Scottish football team as it celebrated qualifying for the Euro finals.
The Fratellis headline appearance comes as they also plan a tour to raise funds for their road crew and independent record stores.
Announcing the band’s appearance at Vibration, Andy said: “After such a successful first event it was a hard pill to swallow not to get to come straight back with year two.
“However we know it’s been such a hard time for everyone and this time has been something we’ve had to get through together.
“The return of the festival means the world to us.”Andy added: “It's a chance for everyone to get together in a fun and safe environment and get back to enjoying themselves again.
“We wanted to deliver another really strong line up and securing The Fratellis is a fantastic achievement.”
He said the full line-up - yet to be disclosed - offers “something for everyone” including well established bands and new emerging acts
Andy added: “We hope the incredible support for Vibration Festival will continue and thank everyone for their patience in getting back to this point - it’s really is in the hands of the people to allow this to grow and become an annual event to be proud of.”
Tickets are on sale now from vibrationfestival.com.
Updates are also available via the festival’s Festival Facebook