The incident happened just after 12.30pm at Matalan, in Carron Road, Bainsford.
A Scottish Fire and Rescue Service spokesperson said: "We were alerted at 12.38pm on Wednesday, November 10 to a fire affecting a commercial building on Carron Road, Falkirk. Operations Control mobilised two appliances to the scene to extinguish the fire. There were no reported casualties.
"Crews left after making the area safe."