Top of the pile is probably the clash between last year’s beaten finalists Pollok and record winners Auchinleck Talbot.
The match between the two Super League giants is a repeat of the 1986 final which Talbot won 3-2.
Kirkintilloch Rob Roy are fancied by many for a lengthy cup run following their scintillating start to the season and have been handed a relatively straight forward looking task against Central League side Glasgow Perthshire.
Thorniewood United will have it all to do against East Superleague champions Bonnyrigg Rose while two of the East Region’s other main contenders - Bo’ness United and Linlithgow Rose - have away matches at Blantyre Vics and Dundee North End respectively.
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Carnoustie Panmure have drawn a trip to Glasgow to face Petershill and Broughty Athletic are also away, at Downfield.
West Super League First Division leaders Kilsyth Rangers are at home to Lochgelly and local rivals Cumbernauld United will entertain Tranent.
But two other Lanarkshire sides face tough away matches with Forth Wanderers at Maryhill and Carluke Rovers travelling to Irvine Vics.
The full draw is -
East Kilbride v Culter
Kirriemuir v Hill of Beath
Kilsyth v Lochgelly
Penicuik v Scone
Haddington v Neilston
Blackburn v Girvan
Thorniewood v Bonnyrigg
Stonehaven v Greenock
Luncarty v Rosyth
Dundee Violet v Glenafton
Dundee North End v Linlithgow Rose
Glasgow Perthshire v Rob Roy
Petershill v Carnoustie
Banks O’Dee or Kilbirnie v Sauchie
Renfrew v Arniston
Dufftown v Dunbar
Gartcairn v Whitburn
Lochee Utd v Musselburgh
Maybole v Benburb
Maryhill v Forth
Blantyre Vics v Bo’ness United
Darvel v Irvine Meadow
Irvine Vics v Carluke
Larkhall v Fauldhouse
Kilwinning v Shettleston
Beith v Islavale
Downfield v Broughty Ath
Kelty v Ashfield
Pollok v Auchinleck
Edinburgh Utd v Maud
Jeanfield v Hermes
Cumbernauld v Tranent
Latest McBookie.com odds following the draw have Auchinleck Talbot as 5/1 favourites.
Favourites: 5/1 Talbot 6/1 Kelty 7/1 Beith 12/1 Pollok 12/1 Bonnyrigg 16/1 Rob Roy 20/1 Kilbirnie 20/1 Glenafton 20/1 Bo’ness 25/1 Linlithgow.
Selected others: 66/1 Kilsyth 100/1 Cumbernauld 100/1 Thorniewood 150/1 Carluke 150/1 Forth.