Emergency services raced to a building in Mansionhouse Road after the alarm was raised.
Police also attended the incident and closed a number of routes including Carmuirs Avenue while fire crews tackled the fire.
A Scottish Fire and Rescue Service spokeswoman said: “We received a call to a fire within a two-storey building at 6.04am this morning in Mansionhouse Road and a number of fire appliances were dispatched and remain at the scene.”
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A Police Scotland spokesman said: “The top of Mansionhouse Road remains closed but restrictions on other routes have now been scaled back. We have no reports of anyone being injured at this time.”
