Police say they are concerned for the welfare of Kaitlyn Christie (14) and Caroline Williamson (16).
They were last seen in Stirling town centre at around 6.20pm on Sunday.
Kaitlyn is described as white, of medium build and with shoulder length brown hair. She was wearing a short-sleeved black jumpsuit.
Caroline is also white and of medium build. She has dyed silver hair with a purple tint and was wearing black leggings, a vest top, khaki shirt and white trainers.
Anyone with information is urged to contact Police Scotland on 101.