Police have been alerted to the incident, which took place on the M80 before Junction 9 Bannockburn on Saturday night.
A woman driving the black Ford EcoSport that was targeted managed to escape with only a smashed windscreen and no injuries.
Sergeant Andy Angus, of Falkirk Police Station, said: “At about 10.10pm on Saturday someone on a bridge over the M80 dropped a brick, striking a vehicle heading north towards Stirling.
“Thankfully there were no injuries to the woman but the windscreen smashed.
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“She didn’t see anybody, just the brick bouncing off the car.”
Anyone travelling in the area at this time, particularly drivers with dash-cam footage, is asked to contact police on 101.
Reports can be made anonymously to Crimestoppers on 0800 555 111.