The incident happened in the Snab Brae area at around 8.50am, at the junction of the A993 and the A904 near Bo’ness. Emergency services were on the scene while the road was cleared.
A 28-year-old woman was taken from the crash scene by ambulance to the hospital.
A Police Scotland spokesperson said: “At around 8.50am on Tuesday, June 29, emergency services received a report of a collision involving a car and van at Snab Brae, at the Bo’ness junction with A993/A904.
“There are no reports of anyone else injured at this time. Enquiries into the circumstances of the collision continue.”