Road and rail users face massive disruption while a bridge is replaced.
Work on the structure over the A9 Stirling Road at Camelon is part of ongoing upgrading work being carried out by Network Rail.
Diversions are being put in place and coaches will be used to transport rail passengers and pedestrians while the work is underway.
However, drivers are being urged to avoid the area if at all possible during this period.
Although the work has been planned for the traditional Falkirk trades holiday period, it is expected that thousands of motorists will be affected.
It will also lead to even more vehicles driving through the heart of Stenhousemuir and Larbert.
As part of the £500,000 project, two 800 tonne cranes will remove the old rail bridges and put the new, replacement structures in place.
These will sit higher above the road and mean there will no longer be a height restriction for vehicles, giving better access to the area.
The busy road will be closed from Friday, July 1 to Friday, July 15.
Over two weekends, July 2 and 3, then July 9 and 10, Camelon railway station will be out of commission with rail passengers having to use a bus replacement service between Cumbernauld and Falkirk Grahamston.
Roads chiefs at Falkirk Council have set up a lengthy diversion route which will add several miles to motorists’ journeys.
It is Stirling Road; Main Street, Camelon; A9 Northern Distributor; Ronades Road; Carron Road; Stenhouse Road; Kirk Avenue; Main Street, Stenhousemuir; Main Street, Larbert; Stirling Road, Larbert; Stirling Road, Falkirk; and vice-versa.A shuttle bus will take pedestrians from one side of the closure to the other while the footpath is closed. The cost of providing this is being met by the bridge contractor.
All bus stops in Stirling Road, Falkirk, from Larbert Cross to Main Street, Camelon, will be out of use during the closure.
A spokesman for Network Rail said: “The work is part of our general programme of renewal to improve the rail service.”
Signs advising of the closure are already in place to warn pedestrians and motorists, while the footpath at the corner of Stirling Road and Nailer Road that leads to the bridge and gives access to Camelon rail station has been closed in preparation for the work.
Householders living nearby have been warned the work is due to start and about the likelihood of disruption and noise on their doorstep during the period of the upgrading.