The most populated parts of Scotland, including Glasgow, Stirling and Lanarkshire, will move from Level 3 to Level 4 of the Scottish Government’s five-tier system at 6pm on Friday.
Across 11 council areas, non-essential shops, hospitality, gyms and hairdressers will be forced to close and people will be told to stay at home as much as possible.
A ban will also come into law restricting people in Level 3 and Level 4 areas from travelling outside of their council boundaries and on all Scots from entering other parts of the UK or Ireland.
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But the First Minister said life could return to some semblance of normality by spring.
Speaking during Friday's Scottish Government daily coronavirus briefing, Ms Sturgeon said: “These restrictions are difficult and we are all scunnered and fed up, and I’m not going to stand here and pretend otherwise because I feel that same sense of being utterly scunnered and fed up as the rest of you do,” she said.
“But we do now see a possible end in sight and I think it’s really important that we don’t forget that.”
The First Minister added: “There is a very real prospect for all of us of a substantially more normal way of life being returned to us by the time we reach the spring of next year.”