The discount retailer is shutting 44 of its stores from this weekend as a result of the fresh Covid-19 restrictions.
A number of premises, including the Poundland in The Howgate Shopping Centre, will be placed into “hibernation” from Saturday.
The company said the vast majority of its 800-plus shops will stay open for business due to its essential retailer status.
The stores which are being shut temporarily have been impacted by an 80 per cent drop in footfall.
Austin Cooke, Poundland retail director, said: “Putting a small number of stores into hibernation helps protect them for the long-term and focus our attention on the majority of stores that remain open to serve their neighbourhoods.
“We hope this lockdown is short and we can reopen our hibernating stores as quickly as possible and we remain grateful for the vital support schemes available to us that help protect jobs.”